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44. An integrated optical biochemical sensor fabricated using rapid-prototyping techniques

Author Chang-Yen, David A.; Gale, Bruce K. ; University of Utah, Mechanical Engineering, Salt Lake City, UT, United States

Source Proc SPIE Int Soc Opt Eng v 4982 2003 p 185-195 Microfluidics, BioMEMS, and Medical Microsystems Jan 27-29 2003 San Jose, CA, United States

Abstract This paper details the design and fabrication of an integrated optical biochemical sensor using a select oxygen-sensitive fluorescent dye, tris(2,2'-bipyridyl) dichlororuthenium(II) hexahydrate, combined with polymeric waveguides that are fabricated on a glass substrate. The sensor uses evanescent interaction of light confined within the waveguide with the dye that is immobilized on the waveguide surface. Adhesion of the dye to the integrated waveguide surface is accomplished using a unique process of spin-coating/electrostatic layer-by-layer formation. Exposure of the dye molecules to the analyte and subsequent chemical interaction is achieved by directly coupling the fluid channel to the integrated waveguide. A unique fabrication aspect of this sensor is the inherent simplicity of the design, and the resulting rapidity of fabrication, while maintaining a high degree of functionality and flexibility. [References: 39] (Auth abstract) XX




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