2001 (and backfills for previous years) / DB reference years
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Author Ikuta-K; Takahashi-A; Maruo-S
Source Proceedings-of-the-IEEE-Micro-Electro-Mechanical-Systems-(MEMS) . n 01CH3709, 0) p 455-458; 14th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2001). Interlaken, Switzerland
Abstract World's first "In-chip cell-free protein synthesis from DNA" in the biochemical IC chips was demonstrated. A luminous protein of firefly "Luciferase" was synthesized from DNA and monitored in real time manner. This micro chemical laboratory was constructed by prefabricated biochemical IC chips proposed and developed by the authors. Each chip was three dimensionally fabricated by using "Hybrid micro stereolithography". Our successful results provide new and strong method demanded from post-genome research to find the relationship between gene and protein. User assemble versatile biochemical IC chips provide us to reduces experimental through put time, the cost of expensive biochemical reagent and apparatus for various kinds of protein. DNA originated cell-free protein synthesis is one of the biggest key technology for not only life science but also medicine and drug discovery. 6 Refs. (Auth abstract) XX