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Final Answers
© 2000-2008 Gérard P. Michon, Ph.D.

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Medicine

A man is as old as his arteries.
Thomas Sydenham   (1624-1689)

 

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Concentrations of blood glucose (bG) in  mg/dL  (cg/L)  or  mmol/L.
Hemoglobin A1c Test
Wikipedia: Glycemia  |  Glycosylated Hemoglobin
 
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Medicine by the Numbers

It is with medicine as with mathematics:  We should 
occupy our minds only with what we continue to know;
what we once knew is of little consequence.

Charles Augustin  Sainte-Beuve   (1804-1869) 

Dr. Rita Rae Fontenot (2006-10-19)   Emergency use of an IU rating.
How do I give 125 IU from poorly-labeled 10 mL vials of 10000 units?

This amounts to 1000 IU per mL.  8 doses per mL.  To administer such a small dose (2 drops) with some precision, you may want to dilute it first.  For example 1 vial in 90 cc of an inactive solution yields 100 cc, from which you get 80 doses of 125 IU (1.25 cc each).  If you're a young doctor by herself in a remote area, I'll just pray that you'll know what to do with whatever means you have at your disposal and whatever help you can gather about this emergency.

What is an  IU  worth ?

The IU (International Unit) is a unit of biological activity which is standardized for each substance (fairly arbitrarily) by the World Health Organization.  It's also abreviated UI (from the French locution  unité internationale ).

For a simple chemical (e.g., Vitamin C) the WHO simply assigns a value of 1 IU to a particular mass of that substance.  The rating of biological preparations (e.g., vaccines) is more delicate but it need not be of concern to the practitioner...

If you need to give 125 IU of a substance to a patient, you must first know the concentration of the solution you have at hand.  Normally, this is shown directly in IU/ml, IU/mL or IU/cc (same thing) on the package.  It could also be given as the reciprocal of that:  For example 1mL/40 IU is the same as 40 IU/mL.


(2007-03-29)   Concentration is amount (grams or moles) per volume.
Blood glucose concentration (bG) is thus given in mg/dL or in mmol/L.

A mole of glucose  (CAS 50-99-7)  weighs  180.16 grams.  Therefore, a blood glucose concentration  (bG)  of  1 mmol/L  is equivalent to  18.016 mg/dL.

So, the blood glucose concentration given in  mg/dL  (the form most commonly used by doctors and diabetic patients across Europe and the US)  is numerically 18 times the number in  mmol/L  (often used in medical research).

Blood Glucose, Plasma Levels   (bG)
mg/dLmmol/L   Interpretation and/or Symptoms  
54030.0 Severe imbalance.
36020.0 Very high blood sugar level.
27015.0 High or very high
(depending on patient)
20011.1
18010.0 Non-diabetic postprandial
(i.e., after meal)
1448.0
1086.0 Non-diabetic preprandial
(i.e., before meal)
100 5.55 
905.0
724.0 Slightly low.  Mild lethargy.
543.0 Quite low.  Lethargy.
362.0 Extremely low.  Risk of fainting.

Whole blood concentration is actually 15% lower than the plasma level quoted above, but modern portable glucose meters are calibrated to match the plasma readings obtained in lab tests.  Venous blood and capillary blood may have slighlty different compositions only when blood chemistry evolves rapidly (after a meal).


(2007-03-29)   Blood Glucose and HbA1c
Glycated hemoglobin buildup indicates average blood glucose (bG).

The table below gives the rough correspondence between HbA1c results (in %) and  long-term average  blood glucose level (bG in mg/dL).  The formula is:

(mean bG, in mg/dL)     =     35.6  (% of A1c hemoglobin)  -  77.3

HbA1c 4.04.14.24.34.44.54.64.74.84.9
Glucose 65697276798386909497
 
HbA1c 5.05.15.25.35.45.55.65.75.85.9
Glucose 101104108111115119122126129133
 
HbA1c 6.06.16.26.36.46.56.66.76.86.9
Glucose 136140143147151154158161165168
 
HbA1c 7.07.17.27.37.47.57.67.77.87.9
Glucose 172175179183186190193197200204
 
HbA1c 8.08.18.28.38.48.58.68.78.88.9
Glucose 208211215218222225229232236240
 
HbA1c 9.09.19.29.39.49.59.69.79.89.9
Glucose 243247250254257261264268272275
 
HbA1c 10.010.110.210.310.410.510.610.710.810.9
Glucose 279282286289293297300304307311
 
HbA1c 11.011.111.211.311.411.511.611.711.811.9
Glucose 314318321325329332336339343346
 
HbA1c 12.012.112.212.312.412.512.612.712.812.9
Glucose 350353357361364368371375378382
 
HbA1c 13.013.113.213.313.413.513.613.713.813.9
Glucose 386389393396400403407410414418
 
HbA1c 14.014.114.214.314.414.514.614.714.814.9
Glucose 421425428432435439442446450453

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