| 1657 | Boston | Measles |
| 1687 | Boston | Measles |
| 1690 | New York | Yellow Fever |
| 1713 | Boston | Measles |
| 1729 | Boston | Measles |
| 1732-3 | Worldwide | Influenza |
| 1738 | South Carolina | Smallpox |
| 1739-40 | Boston | Measles |
| 1747 | CT, NY, PA, SC | Measles |
| 1759 | N. America [areas inhabited by white people] | Measles |
| 1761 | North America and West Indies | Influenza |
| 1772 | North America | Measles |
| 1775 | North America [especially hard hit NE] | epidemic ~ Unknown |
| 1775-6 | Worldwide [one of the worst epidemics] | Influenza |
| 1783 | Dover. DE ["extremely fatal"] | Bilious Disorder |
| 1788 | Philadelphia and New York | Measles |
| 1793 | Vermont | a "putrid" fever & Influenza |
| 1793 | VA [killed 500 in 5 counties in 4 weeks] | Influenza |
| 1793 | Philadelphia [one of the worst epidemics] | Yellow Fever |
| 1793 | Harrisburg, PA [many unexplained deaths] | Unknown |
| 1793 | Middletown, PA [many mysterious deaths] | Unknown |
| 1794 | Philadelphia, PA | Yellow Fever |
| 1796-7 | Philadelphia, PA | Yellow Fever |
| 1798 | Philadelphia, PA [one of the worst] | Yellow Fever |
| 1803 | New York | Yellow Fever |
| 1820-3 | Nationwide [starts-Schuylkill River and spreads] | "Fever" |
| 1831-2 | Nationwide [brought by English emigrants] | Asiatic Cholera |
| 1832 | NY City and other major cities | Cholera |
| 1833 | Columbus, OH | Cholera |
| 1834 | New York City | Cholera |
| 1837 | Philadelphia | Typhus |
| 1841 | Nationwide [especially severe in the south] | Yellow Fever |
| 1847 | New Orleans | Yellow Fever |
| 1847-8 | Worldwide | Influenza |
| 1848-9 | North America | Cholera |
| 1849 | New York | Cholera |
| 1850 | Nationwide | Yellow Fever |
| 1850-1 | North America | Influenza |
| 1851 | Coles Co., IL, The Great Plains, and Missouri | Cholera |
| 1852 | Nationwide [New Orleans-8,000 die in summer] | Yellow Fever |
| 1855 | Nationwide [many parts] | Yellow Fever |
| 1857-9 | Worldwide [one of the greated epidemics] | Influenza |
| 1860-1 | Pennsylvania | Smallpox |
| 1865-73 | Philadelphia, NY, Boston, New Orleans | Smallpox |
| Baltimore, Memphis, Washington DC | Cholera | |
| A series of recurring epidemics of: | Typhus Typhoid Scarlet & YellowFever | |
| 1873-5 | North America and Europe | Influenza |
| 1878 | New Orleans [last great epidemic] | Yellow Fever |
| 1885 | Plymouth, PA | Typhoid |
| 1886 | Jacksonville, FL | Yellow Fever |
| 1918 | Worldwide
[high point yr] more people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps |
Influenza |
