2003 / Solid Freeform Fabrication Proceedings
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Author L. Geng (1), Y. S. Wong (1), D. W. Hutmacher (2), W. Feng (1), H. T. Loh (1). and J. Y. H. Fuh (1); (1) Laboratory for Concurrent Engineering and Logistics, Department of Mechanical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore (2) Division of Bioengineering, Department of Orthopedic Surgery, National University of Singapore 10 Kent Ridge Crescent, Singapore 119260, Singapore
Source Solid Freeform Fabrication Proceedings, 2003, pp 423-432.
Abstract A desktop rapid prototyping (RP) system has been developed to fabricate scaffolds for tissue engineering (TE) applications. The system is a computer-controlled four-axis machine with a multiple-dispenser head. This paper presents the scaffold fabrication process to build free-form scaffolds from relevant features extracted from given CT-scan images for TE applications. This involves obtaining the required geometric data for the scaffold in the form of a solid model from CT-scan images. The extracted scaffold model is then sliced into consecutive two-dimensional (2D) layers to generate appropriately formatted data for the desktop RP system to fabricate the scaffolds. The basic material processing involves the sequential dispensing of two or more materials to form a strand. The four-axis system enables strands to be laid in a different direction at each layer to form suitable interlacing 3D free-form scaffold structures. The multiple- dispenser head also allows the introduction of living cells and a dditional materials during the scaffold building. The building of the scaffolds with the desktop RP system is described based on the sequential dispensing of chitosan dissolved in acetic acid and sodium hydroxide solution. Neutralization of the acetic acid by the sodium hydroxide results in a precipitate to form a gel- like chitosan strand. Keywords: Scaffold; Rapid prototyping; Tissue engineering (Auth abstract) [References: 15] XX
Solid Freeform Fabrication Proceedings can be obtained from: The Solid Freeform Fabrication Symposium
or contact:
The University of Texas at Austin
Laboratory for Freeform Fabrication / Texas Materials Institute
Mechanical Engineering Dept.
c/o The Solid Freeform Fabrication Symposium
MC C2200
Austin, TX 78712-1063 USA
512-471-3026; 512-471-7681 FX; Email: sffsymp@uts.cc.utexas.edu