Selected Publications Claudia Gottstein, MD
1. Gottstein, C., G. Schön, S. Tawadros, D. Kube, U.C. Wargalla-Plate, M.L. Hansmann, H.H. Wacker, F. Berthold, V. Diehl, A. Engert (1994) Antidisialoganglioside ricin A-chain immunotoxins show potent antitumor effects in vitro and in a disseminated human neuroblastoma severe combined immunodeficiency mouse model. Cancer Research 54: 6186-6193.
Cancer Research 1994 - PDF
2. Winkler, U., C. Gottstein, G. Schön, U. Kapp, J. Wolf, M.L. Hansmann, H. Bohlen, P. Thorpe, V. Diehl, A. Engert (1994) Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins. Blood 83: 466-475.
Blood 1994 - PDF
Blood Editorial - PDF
3. Gottstein, C., U. Winkler, H. Bohlen, V. Diehl, A. Engert (1994) Immunotoxins: Is there a clinical value? Annals of Oncology 5, Suppl. 1: S97 – S103.
4. Kapp, U., A. Dux, E. Schell-Frederick, N. Banik, M. Hummel, S. Mucke, C. Fonatsch, J. Bullerdiek, C. Gottstein, A. Engert (1994) Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice. Annals of Oncology 5, Suppl. 1: S121-S126.
5. Engert, A., C. Gottstein, U. Winkler, P. Amlot, S. Pileri, V. Diehl, P. Thorpe (1994) Experimental treatment of human Hodgkin's disease with ricin A-chain immunotoxins. Leukemia & Lymphoma 13, 441-448.
6. Engert, A., C. Gottstein, H. Bohlen, U. Winkler, G. Schön, O. Manske, R. Schnell, V. Diehl, P. Thorpe (1995) Cocktails of ricin A-chain immunotoxins against different antigens on Hodgkin and Sternberg-Reed cells have superior anti-tumor effects against H-RS cells in vitro and solid Hodgkin tumors in mice. International Journal of Cancer 63: 304-309.
7. Gottstein, C., G. Schön, S. Tawadros, M.L. Hansmann, F. Berthold, A. Engert. (1996) A disseminated human neuroblastoma model. In: Immunodeficient Animals: Models for Cancer Research. Contributions in Oncology Vol 51, W. Arnold, P. Koepf-Maier, B. Micheel (Hrsg.) Karger, 193-197.
8. Derbyshire, E.J., C. Gottstein, P. Thorpe. (1997) Immunotoxins. In: Immunochemistry 1: A practical approach. M. Turner, A. Johnston (Hrsg.) Oxford University Press, 239-273.
9. Huang, X., C. Gottstein, R.A. Brekken, P. Thorpe (1998) Expression of VEGF receptor 2 and characterization of its binding to VEGF via surface plasmon resonance. Biochemical and Biophysical Research Communications 252: 643-648.
BBRC 1998 - PDF
10. Schiefer, D., C. Gottstein, V. Diehl, A. Engert. (1999) Antiangiogenesis: A new Approach for Cancer Therapy? [Antiangiogenese: Ein neuer Ansatz in der Tumortherapie?] Medizinische Klinik 94: 570-579.
11. Gottstein, C., R. Forde (1999) In vivo measurement of biodistribution kinetics of radiolabeled compounds in laboratory animals. Biotechniques 27: 934-938.
12. Gottstein, C. (2000) Blood vessels – Target for Cancer Therapy [Blutgefäße – Zielscheibe für die Tumortherapie] Target Forum 3: 4-13.
13. Gottstein, C., W. Wels, B. Ober, P.E. Thorpe (2001) Generation and characterization of recombinant Vascular Targeting Agents from hybridoma cell lines. Biotechniques 30: 190-200.
Biotechniques 2001 - PDF
14. Tur, M.K., S. Sasse, M. Stocker, K. Djabelkhir, M. Huhn, B. Matthey, C. Gottstein, T. Pfitzner, A. Engert, S. Barth (2001) An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines. International Journal of Molecular Medicine 8: 579-584
Int J Mol Med 2001 - PDF
15. Forde R., C. Gottstein, D. Lange. (2001) Improved analytical methodology for the detection of cryptosporidium and giardia. International Environmental Technology 11: 37-39.
16. Gottstein, C., R. Forde (2002) Affinity chromatography system for parallel purification of recombinant proteins. Protein Engineering 15: 775-777.
Protein Engineering 2002 - PDF
17. Philipp, J., A. Dienst, M. Unruh, A. Wagener, A. Grunow, A. Engert, J.W.U. Fries, C. Gottstein (2003) Soluble tissue factor induces coagulation on tumor endothelial cells in vivo if coadministered with low-dose lipopolysaccharides. Arteriosclerosis Thrombosis and Vascular Biology 23:905-910.
ATVB 2003 - PDF
18. Borchmann P., J.F. Treml, H. Hansen, C. Gottstein, R. Schnell, O. Staak, H.F. Zhang, T. Davis, T. Keler, V. Diehl, R.F. Graziano, A. Engert (2003) The new fully human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against Hodgkin lymphoma. Blood 102: 3737-3742.
Blood 2003 - PDF
19. Joussen, A., B. Kirchhof, C. Gottstein (2003) Molecular mechanisms of vasculogenesis and angiogenesis. [Molekulare Mechanismen der Vaskulogenese und Angiogenese.] Der Ophtalmologe 100: 284-291.
Der Opthalmologe 2003 - PDF
20. Unruh, M., A. Grunow, C. Gottstein (2005) Systemic coagulation parameters in mice after treatment with vascular targeting agents. Thrombosis Journal 3:21-33.
Thrombosis Journal 2005 - PDF
21. Gosk, S., C. Gottstein, G. Bendas (2005) Targeting of immunoliposomes to endothelial cells expressing VCAM: a future strategy in cancer therapy. Int J Clin Pharmacol Ther 43: 581-582.
Int J Clin Pharmacol Ther 2005 - PDF
22. Ding, B.S.*/Gottstein C.*, A. Grunow, A. Kuo, K. Ganguly, S.M. Albelda, D.B. Cines, V.R. Muzykantov (2005) Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature.Blood 106: 4191-4198.
Blood 2005 - PDF
*equal first authorship
23. Dienst, A., A. Grunow, M. Unruh, B. Rabausch, J.E. Nor, J.W.U. Fries, C. Gottstein (2005) Specific occlusion of murine and human tumor vasculature by VCAM-1 targeted recombinant fusion proteins. Journal of the National Cancer Institute, 97:733-747.
JNCI 2005 - PDF
JNCI Editorial - PDF
24. Danielyan, K., B.S. Ding, C. Gottstein, D.B. Cines, V.R. Muzykantov (2007) Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema.Journal of Pharmacology and Experimental Therapy 321:947-52.
JPET 2007 - PDF
JPET cover
25. Ding, B.S., N.Hong, J-C. Murciano, K. Ganguly, C. Gottstein, M. Christofidou-Solomidou, S.M. Albelda, A.B. Fisher, D.B. Cines, V.R. Muzykantov (2008) Prophylactic thrombolysis by thrombin-activated latent pro-urokinase targeted to PECAM-1 in the pulmonary vasculature. Blood 111:1999-2006.
Blood 2008 - PDF
26. Gosk, S., T. Moos, C. Gottstein**/G. Bendas** (2008) VCAM-1 directed immunoliposomes selectively target tumour vasculature in vivo. Biochimica et Biophysica Acta 1778:854-863.
BBA 2008 - PDF
**equal last authorship
27. Dane, K., C. Gottstein, P.S. Daugherty (2009) Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes. Molecular Cancer Therapeutics, in press.
Molecular Cancer Therapeutics 2009 - PDF
Suppl
28. Ding, B.-S., N. Hong, M. Christofidou-Solomidou, C. Gottstein, S.M. Albelda, D.B. Cines, A.B. Fisher, V.R. Muzykantov (2009) Anchoring fusion thrombomodulin to endothelial lumen protects from lung thrombosis and inflammation. American Journal of Respiratory and Critical Care Medicine, in press
American Journal of Respiratory and Critical Care Medicine 2009 - PDF